Hot from the press!
antidepressants in pregnancy are linked to ADHD but not to autism, says study
medication use during pregnancy
contralateral mastectomy after breast cancer beneficial in carriers of BRCA1 and BRCA2
life style
modifications and risk of PET
hormone contraception linked to gestational diabetes
acupuncture & menopausal symptoms
restriction on bromocryptine for lactation in EU
neonatal outccomes with
cord-clamping after spontaneous
resiration
pertussis vaccination & pregnancy BMJ 2014
maternal peanut consumption and childhood allergy Frazier et al. JAMA Pediatr. 2014 Feb;168(2):156-62
FDA approves HPV test for 1ry. screening for cervical cancer
weight gain in the 1st. postpartum year increases diabetes risk
outcomes of women with postcoital bleeding
undiagnosed coeliac disease in infertile women
peritoneal cytology and outcome in stage III endometrial cancer
costs of robotic surgery for radial hysterectomy + lymphadenectomy
VTE risk with minimally invasice surgery for ca cx and endometrium
screening for HNPCC in women with endometrial cancer
vitamin D: MRC trial of maternal levels and bone mineral content in late childhoo
vitamin D: systematic review: FGR, GDM
and PET.
BMJ. 2013 Mar 26;346.
does anti-smoking legislation reduce preterm births
does periconceptual folic acid reduce the
risk of autism?
dietary cadmium and ovarian ca risk
induction of labour for postmaturity increases Cs rates
risk factors for delayed postpartum eclampsia
risk factors for emergency postpartum hysterectomy
VX-770 shows promise in cystic fibrosis
does waterbirth increase the risk of third degree tear?
chorioamnionitis, mycoplasmas and PPROM
timing of primary maternal CMV infection and risk to fetus and neonate
prenatal exposure to organochlorine pesticides and birth weight
placenta accreta linked to IVF
remission of maternal depression has beneficial effect on children
Cochrane Review: non-clinical intervemtions for reducing unnecessary C sections
is antenatal screening for syphilis still worthwhile?
first report of reduced high-grade cervical abnormalities after introduction of HPV vaccination
is same-day discharge safe after laparoscopic hysterectomy?
mimally invasive hysterectomy reduces complications without increasing cost
ovarian cancer screening does not work: PLCO
should pregnant women sleep on their left?
maternal sleeping position and stillbirth
incontinence in women having only C. section births
risks & benefits of oophorectomy at the time of hysterectomy from the WHI study
how long do hot flushes persist?
early use of the etonorgestrel implant does not impair lactation
more minimally invasive hysterectomy does not mean more complications or higher costs
same day discharge after lap hysterectomy
hysterectomy no panacea in chronic pelvic pain
risk factors for stillbirth in high income countries
morbidity and mortality of surgery for endometrial cancer in the aged
assisted conception and early-onset PT
is SLE linked to a reduced risk of breast, endometrial and ovarian cancer?
cervical cancer: why does screening fail?
LNG IUS v. COC for menorrhagia
are D&E safer than labour induction for second trimester TOP for fetal abnormality / death?
valsalva v. spontaneous pushing in the second stage
does prenatal infection increase the risk of schizophrenia?
could hCG have a role in chronic pain management?
is the menopause a risk factor for depression?
emotional distress does not affect success rates of ART
misoprostol vaginal insert for induction of labour
LNG IUS in women with inherited bleeding disorders
is oral dryness a marker for osteoporosis in postmenopausal women?
IUCD location in early pregnancy
HRT v. soya and placebo for hot flushes
patient safety initiative reduced adverse obstetric outcomes
active and passive smoking and breast cancer
prenatal v. postnatal surgery for myelomeningocoele
levonorgestrel IUS and breast cancer risk
eclampsia < 34/52 - ? delay delivery for steroid administration
laparoscopic versus vaginal hysterectomy: meta-analysis
transfusion rate and prevalence of significant antibodies in hysterectomy for benign disease
ALSO training effective in preventing and managing PPH in developing country setting
Cs scar defects on USS and risk of dehiscence / rupture in future pregnancy
women with puerperal psychosis commonly have auto-immune thyroid dysfunction
gabapentin effective for menopausal hot flushes
research fraud hits colloid versus crystalloid debate
subcuticular suture better than staples for skin closure at Cs
foley catheter as effective as prostaglandin in cervical ripening
breast cancer risk and time of starting HRT
1st. trimester opiod analgesics and possible teratogenic effects
vaginal danazol for rectovaginal endometriosis
sodium valproate exposure in-utero increases risk of impaired language skills
conservative management of early cervical cancer
obesity and endometrial cancer
treatment of vaginal infection and premature delivery rate
infra-red spectroscopy and endometrial cancer diagnosis
efficacy of thromboprophylaxis in pregnancy
transabdominal cervical cerclage
24 v 21 day COCs and drosperinone- containing COCs v others
immediate v. later IUCD insertion after TOP
2nd. trimester uterine evauation and maternal morbidity
clinical factors affecting TVS accuracy in 1st. trimester pregnancy with pain or bleeding
stress does not reduce efficacy of fertility treatment
is placenta accreta best managed in a tertiary centre?
interpregnancy interval after miscarriage and pregnancy outcomes
early-onset IUGR and abruption linked to Breus' mole
what women with recurrent miscarriage want as support in the next pregnancy
small fibroids that do not encroach on the cavity do not have adverse effect on IVF success rates
prematurity rates reduced by infection screen in early pregnancy
thrombo-prophylaxis and risk of recurrence
24 day and 21 day COCs with drosperinone or norethiseterone: efficacy compared
NIH v Rotterdam criteria for predicting early pregnancy abnormalities
incontinence after obstetric anal sphincter damage
spinal anaesthesia better than GA in recovery after abdominal hysterectomy
insulin resistance has negative impact on outcomes after ovarian diathermy in PCOS
adnexal mass size and risks of malignancy and torsion in pregnancy
race, inter-pregnancy interval and pre-term birth
diabetes, obesity and infection after C. section
cancer screening for women from HNPCC families
interleukin-6 and gestational diabetes
probable transmission of yellow fever in breast milk after maternal vaccination
non-invasive testing for trisomy 21
nifedipine v. mag. sulphate and beta-sympathomimetics in premature labour
prenatal x-rays and fetal risk
prenatal v. postnatal repair of myelomeningocoele
screening tool for bleeding disorders in women with menorrhagia
simple IOTA-based ultrasound rules to predict malignant potential of adnexal masses
cord milking v. delayed cord clamping
radical trachelectomy and fertility
falloscopic tuboplasty for tubalinfertility
smear history in women who develop cx cancer
cocaine use and pregnancy outcomes
breast cancer risk and interval from menopause to starting HRT
editorial on breast cancer risk and interval from menopause to starting HRT
TOP in 1st. trimester and risk of mental disorder
cigarettes and breast cancer risk
breast cancer patients on anti-oestrogens have lower incidence of lung cancer
black cohosh for menopausal symptoms in women on tamoxifen after breast cancer
does LMWH for prevention of VTE in pregnancy / puerperium work?
can metformin reduce GDM andPET rates in women with PCOS
i.v. Ig and recurrent miscarriage
chronic endometritis and recurrent miscarriage
abruption: epidemiology, risk factors and outcomes
is this labour or not? - value of electromyography
oxytocin of no value in 1st. trimester surgical TOP
genetic contribution to functional amenorrhoea
cranberry juice disappoints in UTI recurrence trial
maternal age, gestation and risk of fetal death
in-utero AED exposure and verbal & non-verbal skills at 3 years
abandon indwelling catheters for Cs?
nifedipine less effective that terbatuline for ECV, in fact, not much good at all
short interpregnancy interval linked to increased autism risk
hysterectomy as risk factor for cardiovascular disease
LNG-IUS, cervical mucus and sperm penetration
management of menopausal symptoms in breast cancer patients
pregnancy outcomes in IBS treated with antiTNF
HRt and dementia risk - is timing all important?
should all women with stage IIIc endometrial cancer have para-aortic lymphadenectomy?
hysteroscopic resection best for isthmocele?
Activin A levels reduced in tubal pregnancy
duration of antibiotic therapy after septic miscarriage
synechiae common after uterine compression sutures for PPH
Dicletin (Debendox) returns from the dead
LNG-IUS, cervical mucus and sperm penetration
MHRA issues warning re Implanon and introduces nexplanon
2 doses of varicella vaccine much better than 1
pregnancy after abruption in previous pregnancy
new uterine compression suture for PPH
dynamic spectral imaging colposcopy
PCOS and ovulation induction: SOGC
should hycosy be a first-line investigation?
chewing gum contraception - what next?
PPIs and risk of congenital abnormality
incidence of maternal and paternal postnatal depression
is it time to redfine normal progress in the first stage?
gestation important to neonatal outcome, not juust lung maturity
donor eggs increase the risk of PET
PCOS and long-term risk of diabetes and dyslipidaemia
factors linked to severity in atonic PPH
outpatient bi-polar radio-frequency ablation v. thermal balloon
expectant management OK for unexplained infertility
temporary uterine artery occlusion may be useful adjunct to laparoscopic myomectomy
huge differences in obstetric anal sphincter damage rates in Finland
is the increasing incidence of impaired glucose intolerance all down to increasing obesity rates?
oxytocin effective for active management of the 3rd. stage even if used for augmentation of labour
wound complications postCS and exoxaparin
denufosol, a new ion-channel regulator shows promise in children with CF
FDA approves use of Safyral, a COC with folate
should D-dimer assay help with the management of PID?
Belgian audit showing sub-optimal care for rape complainants. Do we do better?
pre-operative scintillography and blue dye for sentinel node identification in vulval cancer
analgesics in pregnancy and childhood leukaemia
outcomes for women in an observational study of CIN3
eight-year follow-up after hydrothermal ablation for menorrhagia
miscarriage and stillbirth and risk of myocardial infarction
enoxaparin and recurrent miscarriage
fertility and pregnancy outcomes after conservative management of placenta accreta
reassuring news about chemotherapy for breast cancer in pregnancy from the San Antonio Breast Cancer Symposium 2010
endometrial cancer risk in users of HRT
TVS screening for endometrial cancer from UKCTOCS
serum AMH levels and live birth rates
carbamazepine and congenital malformation
neonatal abstinence syndrome after maternal methadone or buprenorphine
fertility preservation and breast cancer
different doses of enoxaparin in management of recurrent miscarriage in women with APS
oral rivaroxaban looking good for DVT and PE, but not yet in pregnancy
cone excision + laparoscopic lymphadenectomy to preserve fertility in early cervical cancer
jaundice and the breastfeeding infant
breastfeeding guideline from Academy of Breastfeeding Medicine
repeated miscarriage an indicator of increased MI risk
psychiatroc drugs and pregnancy
thyroid levels and pregnancy loss
donor and cryo-preserved eggs appear to increase the risk of hypertensive disorders of pregnancy
LNG-IUS more effective than COC in reducing menstrual bleeding in women with fibroids
antenatal depression: prevalence and risk factors in USA population
length of 1st. stage and maternal and neonatal outcomes
proton pump inhibitors appear safe in early pregnancy
smoke in pregnancy and see your child arrested?
TVS and MR comparable in the diagnosis of adenomyosis
paediatric gynae surgery particularly prone to foreign bodies being left behind
are AN steroids contra-indicated when there is chorio-amnionitis? BJOG article.
endometrial polyps and risk of cancer
fibroids and obstetric outcomes
E2 only HRT does not increase risk of lung cancer
400 v 800ľg misoprostol after mifepristone for early TOP
experimental drug shows promise in early trials in CF
Placental Growth Factor: a possible marker for ectopic pregnancy
reproductive outcome after childhood cancer
mild analgesics a risk factor for cryptorchidism?
morbidity after obstetric anal sphincter injury repair in the UK
placenta accreta: statement by Society for feto-maternal medicine
factor V Leiden, VTE and pregnancy complications
BV diagnosis at 16-21 weeks not linked to early delivery
impaired glucose tolerance short of formal GDM still linked to adverse outcomes
attempted suicide and suicidal thoughts in pregnancy in Karachi
breast-feeding does not cause more maternal sleep disturbance than artificail feeding
risk factors for SB in the USA
unplanned pregnancy and anorexia nervosa
surgical safety checklist reduces complications and mortality
17-OH progesterone of no value in triplet pregnancy
can exercise reduce the risk of .endometrial.cancer?
Apgar score and cerebral palsy
neonatal jaundice and autism and other disorders of psychological development
recombinant factor VII and thrombosis risk
PNMR and style of pregnancy care in the Netherlands
place of delivery and outcome: BMJ editorial
anti-depressants in pregnancy and IUGR
degree of cervical invasion as predictor of death in stage II endometrial cancer
fibroids and pregnancy outcome
pregnancy outcomes at advanced maternal age
does hyperemesis gravidarum have a hereditary component
pre-implantation aneuploidy screening may improve IVF success rates
prevalence of hyperprolactinaemia in newly-diagnosed hypothyroidism
training programme appears effective in reducing anal sphincter damage
HRT and breast cancer: more bad news from WHI
reassuring 2-year follow-up after in-utero exposure to fortnightly steroids
levonorgestrel IUS v. GnRH analogue after laparoscopic treatment of endometriosis
short cervical length linked to increased risk of APH in women with placenta previa
polytherapy for epilepsy linked to reduced fertility
variation in C. section rates across Trusts
midwife training reduces perinatal mortality in a developing country
is appendicectomy during laparoscopic surgery for endometriosis worthwhile and safe?
UAE plus curettage for cervical pregnancy
three year follow-up after anterior colporrhaphy with and without mest
severity of pregnancy nausea and vomiting inversely linked to miscarriage risk
progesterone ineffective in prolonging pregnancy after PPROM in small study
is vitamin D a risk factor for bacterial vaginosis in pregnancy?
small study suggests women prefer surgical to medical TOP in the second trimester
low Apgar score and risk of cerebral palsy
fall in breast cancer incidence linked to reduced HRT use in Canada
new evidence possibly implicating angiotensin in the aetiology of PET
artemether-lumefantrine as 1st. line treatment for malalaria: effective and acceptable
artemether-lumefantrine evaluated for treatment of malaria in pregnancy: effective and seems safe
light drinking in pregnancy appears safe for progeny at 5 years
hormonal contraception and risk of endometrial cancer
Debendox (Benedictin) reborn as Dicletin: a real-life Phoenix
do we need separate gestation assessment charts for male and female fetuses?
IUGR linked to increased of febrile seizures
antibiotic prophylaxis for outpatient hysteroscopy?
screening tool for substance use in pregnancy
short sleep duration linked to increased PET risk
Cs and PPH rates higher for women reaching the 2nd. stage after induced labour
ACOG backs CDC recommendation that pregnant women get 'flu vaccine
9% of American adults are depressed according to the CDC
fetal anomaly risk in obese women: is it due to diabetes?
preop GnRH of no benefit for hysteroscopic removal of submucous fibroids
levonorgestrel intrauterine device + GnRH as Rx for atypical endometrial hyperplasia and carcinoma
lymphadenocetomy in early crvical cancer
overlap v. end-end repair for anal sphincter injury
risk factors for endometrial cancer < 40 yrs
trainees and laparoscopic management of ectopic pregnancy
formula to improve use of amniotic WBC counts is suspeccted amnionitis with "bloody taps"
FDA approved COC with folic acid
breast cancer incidence fell in Canada after WHI study published in 2002
efficacy of risk-reducing mastectomy and oophorectomy in BRCA1 and BRCA2
universal screening for 21-hydroxylase deficiency CAH advocated
metformin & type 2 diabetes in pregnancy
lichen sclerosis of the vulva and moderate potency topical steroids
doxylamine and piridoxine effective for pregnancy nausea
calcium supplementation in pregnancy and dental caries in children at age 12
2nd. trimester blood test to predict later pre-eclampsia
galactogogues: safety and efficacy
betamethasone pharmokinetics, body weight and multiple gestation
technique for loop excision with IUCD in situ
persistent HPV predicts recurrence of CIN 2 & 3 after loop excision
"PhysiScore" effective in predicting morbidity in the preterm
parental depression from child's birth to 12 years
Cochranel finds little evidence to support current treatments for early pregnancy nausea & vomiting
genetic factors in ovarian clear cell carcinoma
artificially sweetened drinks may increase risk of premature labour
smoking, protamine and potential effect on male fertility
cigarette smoking in early pregnancy may reduce potential fertility of offspring
intimate partner violence and maternal depression
inhibin B, elevated LH and amenorrhoea
factors predicting hysterectomy and end organ damage in major PPH
is male hormonal contraception feasible?
usefulness of endocervical curettage at colposcopy
women with CMV infection at increased risk of PET
failed VBAC increases risk to mother and baby in Nigeria
more obstetric intervention = more PPH
oral misoprostol v. i.v. oxytocin for labour augmentation
umbilical vein oxytocinon reduces PPH
oral bisphosphonates linked to increased oesophageal cancer risk
new system proposed for categorising stillbirth
universal screening for thyroid disease in pregnancy?
perinatal mortality less for very LBW and premature babes in tertiary centres
cerebral palsy increased with pre-T and post-T birth
universal screening for FNAIT may be feasible
daily text m essaging does not improve compliance in OC users
safety of acyclovir, valacyclovir and famciclovir in the first trimester
BMI and pregnancy outcomes in nullipara
oral hypoglycaemic drugs v. insulin in gestational DM
women's knowledge of and attitude to alcohol consumption in pregnancy
maternal depression and anxiety linked to low birthweight in Bangladesh
breastfeeding reduces the risk of type 2 diabetes
migraine with aura and CVS and other mortality risk
does abnormal uterine peristalsis contribute to infertility in women with intramural fibroids?
postmenopausal oestrogen and testosterone do no boost brain functioning
screening of all pregnancies for FNAIT advocated
psychological reaction to miscarriage by gender
antenatal exposure to organophosphate pesticides linked to ADHD
children with ADHD have higher levels of organophosphate pesticide metabolites in urine
oxytocin levels in new parents and parenting behaviour
smoking cessation < 16 weeks normalises IUGR and pre-term delivery rates
PCOSMIC Trial: no evidence of benefit in infertility of metformin over standard care
early puerperal DMPA not linked to PND
methamphetamine use identifies American women with multiple high risks and bad outcomes
forceps linked to levator damage
satisfaction with hysterectomy, IUS and endometrial ablation
weight gain in pregnancy linked to increased birthweight
oral misoprostol as effective for labour augmentation as i.v. syntocinon
levonorgestrel IUS superior to oral MPA for menorrhagia
vaginal probiotic effective in recurrent bacterial vaginosis
pulmonary embolism & pregnancy
conservative management justified in simple ovarian cysts in the menopause
late pre-term birth linked to increased respiratory problems
metformin no help in infertility and PCOS?
maternal cigarettes and psychiatric illness in the offspring
is PET a risk factor for hearing loss?
thyroid peroxidase antibodies and abruption
HRT & breast cancer: Californian Teachers' Study
experience managing menopausal symptoms after breast cancer
osteoporosis management in the pre-menopausal
COC with drospirenone superior to one with desogestrel in PCOS
puerperal administration of DMPA does not alter incidence of PND
IPV, pregnancy trauma and risk of abruption
SB and NND rates increase after uterine and ovarian irradiation for childhood cancer
SSRIs and fetal cardiac defects
ectopic pregnancy - why is it missed?
hospital policies can improve uptake of PM after SB
perinatal outcomes worse for non-spontaneous dichorionic twins
fetal PR interval and obstetric cholestasis
maternal smoking and psychiatric illness in adolescent offspring
low-dose aspirin reduces the risk of PET in women at increased risk
pregnancy outcomes after miscarriage and interval to the next pregnancy
IOL doubles the risk of C. section
obstetric complications may increase risk of PND
ulipristal can delay follicular rupture
long-term follow-up reassuring in congenital toxoplasmosis
thrombophilia and unexplained infertility
laparoendoscopic single-site surgery (LESS) in gynaecology
UAE v hysterectomy: 5 year follow-up from EMMY trial
smoking doubles the risk of adverse neonatal outcomes in PET
psychological reaction to miscarriage in men and women
acupuncture ineffective for labour induction
mesh for prolapse repair: randomised trial
respiratory problems with late preterm birth
cardiac dysfunction in survivors of childhood cancer
anti-TPO antibodies triple abruption risk
ultrasound features prior to miscarriage and risk of aneuploidy
risk factors for postterm pregnancy and Cs after induction of labour
new VBAC guideline from the ACOG
home birth linked to tripling of the neonatal mortality rate
quadrivalent HPV vaccine effective at 4 years
obesity, preterm birth and IUGR
Mirena v. DMPA as long-term maintenance treatment for endometriosis
does IVF increase the risk of childhood cancer?
antidepressant use in pregnancy and ADHD in the offspring
comparison of simple and extended hysterectomy for stage 1 endometrial cancer
obese women more likely to have unplanned pregnancy
out-of-hours birth increases risk of anoxic neonatal death
weight loss helps hot flushes in overweight menopausal women
pre-operative check: might she be pregnant? National Patient Safety Recommendations
is smoking a risk factor for endometriosis?
expert recommendations re Turner syndrome and egg donation
adverse intra-partum events and cerebral palsy
early puberty and psycho-social outcomes
ART and HIV transmission between heterosexual couples
VTE, tamoxifen and Factor V Leiden
up to 42% of low Apgar scores linked to substandard care in labour
low PAPP-A linked to SGA and stillbirth risk
valproic acid and major congenital anomalies
in relation to the above, don't forget AED exposure and intellectual development in the child
early preterm delivery, even by a week or two, increases the risk of special educational needs
weight gain in twin pregnancy and risk of adverse outcome
trends and risk factors in 3rd. and 4th. degree tears
end-to-end repair best for anal sphincter tears
endometrial thickness and cancer in women with PMB
prevalence of uterine cavity abnormalities in women planning IVF
age and menarche and early dysmenorrhoea and risk of endometriosis
single-layer closure at Cs doubles risk of uterine rupture
VBAC: < 18/12 interval between pregnancies increases uterine rupture risk
DMPA efficacy and the extremely obese
antibiotics v. lactobacilli for puerperal mastitis
early-onset PET in 1st. pregnancy as predictor of complications in normotensive second pregnancy
maternal exposure to mobile phone base stations not linked to childhood cancer
what should be the upper limit for TSH in the 1st. trimester?
ovarian failure rates after UAE and routine surgery for fibroids
nocturnal birth more hazardous for babies
enoxaparin for thromboprophylaxis during pregnancy in women with mechanical heart valves
HAART to reduce vertical transmission of HIV during breastfeeding in Botswana
levonorgestrel EC before and after ovulation
azithromycin v. penicillin G for early syphilis
transdermal v. oral HRT and stroke risk
NGC guideline on screening for osteoporosis
is ectopic pregnancy more common after failed EC?
LMWH and UFH plus aspirin for recurrent miscarriage in aPS
local haemostatic treatment of bleeding due to placenta previa
significance of intracardiac echogenic focus in population screened for DS in the 1st. trimester
catamenial pneumothorax and endometriosis
implementation of 1st. trimester DS screening
value of removing endometrial polyps
BRCA screening in women with ovarian cancer - are we doing as well as we should?
antidepressants and miscarriage
antibody shows promise in ovarian cancer
sodium valproate monotherapy and congenital abnormalities
morbidity associated with planned hysterectomy for placenta accreta
do hCG levels predict outcome after methotrexate treatment of ectopic pregnancy?
should mild gestational diabetes be treated?
morbidity and mortality of obstetric hysterectomy
obstetric hysterectomy safer in busy units
chlorhexidine wipes do not reduce maternal or neonatal morbidity and mortality
thyroid function testing and drug monitoring in pregnancy
metoclopramide v. promazine for hyperemesis gravidarum
first trimester bleeding and problems later in pregnancy
vitamin A needed for fetal lung development
cutaneous neonatal lupus predicts increased risk of cardiac lupus in the next child
IVIG does not prevent SLE-linked neonatal heart block
ospemifene effective in vulvo-vaginal atrophy
OC of benefit after surgical excision of ovarian endometriomas
multiple marker assay for screening for ovarian cancer
is ovarian cancer screening any nearer?
paternal depression: pre and post-partum
chance of unexpected serious uterine pathology at time of prolapse surgery
amniotic fluid embolism risk factors
four-phasic OC, Natazia, licensed in the USA. Already licensed as Qlaira in Europe.
epidural morphine v. parenteral opioids after Cs.
UV exposure in the 1st. trimester and MS risk if offspring
Implanon effective for teenage mothers
raloxifene and mortality from all causes
LNG EC only effective before ovulation
d abuse and later-life problems
HPV-linked cervical and vulval cancer may have different genetic variations
17-HP ineffective in women at risk of pre-term delivery
embolisation effective in obstetric haemorrhage
BV, inflammatory-response genes and premature delivery
International Association of Diabetes & Pregnancy Study Groups: recommendations on hyperglycaemia
metoclopramide v promethazine for hyperemesis gravidarum
first trimester bleeding_and_complications later in pregnancy and in the next pregnancy
neuro-development after pre-natal surgery for myelomeningocoele
simple ovarian cysts in older women
SPIN: LMWH and LDA in recurrent miscarriage
FDA warns of liver damage from PTU
BMI & accurate obesity measurement can be improved
bupropion & female libido: treatment of HSDD
tubal twin pregnancy treated with methotrexate
bleeding and patient satisfaction with replacement levonorgestrel IUSs
probiotics reduce NEC and mortality rates in premature babes
US Preventive Services Task Force recommends universal screening for syphilis in pregnancy
congenital syphilis rate increased in the USA
incontinence in pregnancy and the puerperium
HPV screening on self-collected specimens for women who don't attend for routine screening
fibroid shrinkage and aromatase inhibitors
DMPA-induced bone loss mostly reversible in adolescents
bariatric surgery and hypertensive disorders in pregnancy
TVS and endometrial evaluation in women on tamoxifen after breast cancer
aspirin use and breast cancer survival
analgesia use and postmenopausal oestrogen levels
behavioural therapy v. continence pessary for stress incontinence
does chlamydia screening work? BMJ editorial on the POPI trial
maternal and neonatal outcomes by place of birth in the USA
vitamin C & E do not improve outcomes in pregnancy hypertension
HART Study: comparison of HPV and cytology screening at 5 years
microsurgery for tubal infertility still a valid option
the Norwich DEFAB risk assessment tool for endometrial cancer
predicted benefit of HPV vaccination in the UK
prognostic value of UA Doppler in early PET
adjustment to TOP for fetal abnormality
number of epidural top-ups linked to uterine rupture risk
insulin rarely needed for glycaemic control in GDM
vitamin D deficiency linked to pelvic floor disorder risk
"care bundles" reduce mortality rates in acute hospitals
potential fertility after chemotherapy for Hodgkin lymphoma
DVT: anatomic distribution in pregnancy
aspirin ineffective in recurrent miscarriage
MRI best for breast cancer screening in women from increased-risk families
perinatal mortality increased x 10 for triplets compared to singletons
RCGP study: OC does not increase mortality
long-term COC use reduces endometrioma recurrence after laparoscopic excision
reducing hospital MRSA infection rates
mifepristone reduces IMB in women using levonorgestrel IUS
CT use in assessing placental damage in acute trauma
HPV vaccine and miscarriage risk
HPV vaccine may not be of much value in women > 25 years
Committee opinion: MgSO4 for fetal neuro-protection in anticipated pre-T delivery
fertility-sparing surgery effective in stage 1A1 cervical cancer
home HPV testing effective in women reluctant to have routine Cx screening
frameless LNG-IUS: clinical experience
CBT can improve pregnancy outcomes in women with environmental smoke exposure
conservative management of placenta accreta feasible, but at some maternal risk
labour, elective CS and transient tachypnoea of the newborn
ADPSGs' recommendations on the diagnosis and classification of diabetes in pregnancy
brachytherapy v. traditional external beam radio-therapy in endometrial cancer: PORTEC-2
accuracy of pathological diagnosis in women with atypical endometrial hyperplasia
obstructive sleep apnoea and pregnancy: prediction and effect on CTG
another report in favour of lymphadenectomy, even in early-stage endometrial cancer
sexual and reproductive health: lesbian and bi-sexual women
inherited thrombophilia and pregnancy outcome
diabetes rather than obesity linked to raised congenital anomaly risk in obese women
Dr conceives naturally after ovarian tissue transplant after chemotherapy
HPV testing preferred to follow-up smear after borderline report
osteoporosis treatment reduces mortality in those at high risk of fracture
HRT & CHD risk: is there ever a reduced risk? More from WHI
thermal balloon ablation v IUS for menorrhagia
hysterectomy or IUS for menorrhagia: long term urinary symptoms
intra-uterine exposure to anti-depressants may delay infant development
rapid weight gain in early pregnancy linked to increased risk of GDM
England's chlamydia screening programme slammed by MPs
contraction of polypropylene mesh: a nasty complication of vaginal prolapse surgery
excellent Lancet review of liver disease in pregnancy
oestrogen and IUD do not prevent adhesions after hysteroscopic resection of uterine septa
treatments for early Cx cancer that conserve fertility
enlarged yolk sac linked to miscarriage and premature labour
plasma cell-free DNA and ovarian cancer prognosis
plasma fibrinogen levels and endometrial cancer prognosis
infection of immune women with new CMV strains a significant cause of neonatal damage
prophylactic mastectomy effective for BRCA mutation carriers
misoprostol for PPH in women given prophylactic oxytocinon for the 3rd. stage
misoprostol for PPH in women not exposed to oxytocinon
HPV screening useful in women with atypical glandular cells on smears
NAMS statement on osteoporosis management
reasons for hospital readmission
some antidepressants impair tamoxifen efficacy
paroxitene and tamoxifen efficacy
universal screening for thyroid disease in pregnancy
internal tocodynamometry no better than external
higher birthweight increases risks in attempted VBAC
chemo-radiotherapy & cervical cancer: Cochrane Review
HPV types and cervical cancer in Scotland
MS and epilepsy: obstetric outcomes
breast feeding and risk factors for cardiovascular disease
should all Jewish women be screened for BRCA founder mutations?
SSRIs may increase mortality rate in women on tamoxifen after breast cancer
childhood cancer treatment increases later cardiovascular disease risk
HRT linked to increased asthma risk
maternal and fetal genes influence preterm delivery risk
maternal antenatal depression linked to teenage violence in offspring
placenta previa but not adverse perinatal outcome more common after IVF in Japan
paternal age, birthweight and height influence risk of SGA and premature delivery of offspring
treating periodontal disease does not reduce premature delivery rates
peptic ulcer disease linked to IUGR and premature delivery
black cohosh and red clover do not relieve hot flushes, but are probably safe
menstrual blood loss at the menopause
PCOS: diagnosis and investigation
hirsutism: anti-androgen treatments
hormonal emergency contraception: mechanisms of action
threatened miscarriage in 1st. trimester linked to adverse maternal and fetal outcomes
NAMS 2010 "position statement" on management of postmenopausal osteoporosis
neonatal urinary tract dilatation and uretero-vesical junction obstruction: European guideline
simple ovarian cysts in postmenopausal women
PCOS: ovarian diathermy v clomiphene + metformin; fertility outcomes
risk reduction model for BRCA1 & 2 carriers
does paracetamol reduce the risk of birth defect in 1st. trimester febrile illness?
HPV screening more effective than cytology in women > 35 years
internal uterine pressure monitoring no better than external
pregnancy outcome after inadvertent HPV vaccination: no evidence of added risk
anti-HIV treatment restricted to pregnancy may increase subsequent drug resistance
tibolone v. standard HRT: menopausal symptoms and sexual function
Cochrane review: food & fluid intake in labour
Cochrane review: Doppler & high-risk pregnancy
benefit of pre-delivery diagnosis of placenta accreta
high soya intake may reduce risk of endometrial and ovarian cancer
high soya intake safe and maybe beneficial after breast cancer
glyburide v metformin in gestational diabetes
women's expectations for pregnancy management after previous unexplained stillbirth
most women find OP hysteroscopy acceptable
risk factors for persistent GTD
cytomegalovirus reinfection in pregnancy
SIGN guideline: management of genital chlamydia
American Urological Association guideline on stress incontinence
most atypical squamous cervical cells regress within 2 years in HPV negative women
chemoradiotherapy and cervical cancer: Cochrane review
no evidence of benefit from restriction of food and fluid in labour: Cochrane review
sublingual misoprostol effective for 1st. trimester TOP
management of hot flushes in women with breast cancer
survival to 2o years of babies born with congenital abnormality
maternal & fetal outcomes after anti-depressant use in pregnancy
umbilical vein oxytocin ineffective for retained placenta: Release study
WHO advises Cs should only be done on medical grounds
repeat chlamydia infections in young women in a screening programme in the USA
women's ideas of what is prematurity
HPV vaccine appears safe in pregnancy
misoprostol as effective in PPH in women who have had routine third-stage oxytocin
misoprostol effective in PPH in women who have not had third-stage oxytocin
severity of H1N1 'flu and pregnancy
post-op infection rates can be halved in nasal carriers of staphylococcus aureus
chlorhexidine-alcohol superior to povidone-iodine as skin prep
mode of delivery & haemophilia
Lynch type II families and gynaecological cancer
PIGD effective for carriers of translocations who have history of recurrent miscarriage
management of ovarian cancer in pregnancy
accuracy of estimation of obstetric haemorrhage improved by training
LUS thickness after elective LSCS and LSCS in labour
herbal product use before and in early pregnancy in the USA
airbags reduce maternal injury with no apparent increase in pregnancy problems
amniocentesis technique using vacuum tubes rather than syringes
black cohosh and red clover ineffective for menopausal symptoms
MEPREP: a new FDA programme to analyse risk of drugs in pregnancy
biomarkers and ovarian cancer screening
high-dose inhaled steroids for asthma in 1st. trimester and risk of fetal anomaly
AEDs and cognition in the offspring
thrombophilia polymorphisms and pregnancy complications
prothrombin gene G20210A and pregnancy complications
placenta accreta: effect of pre-labour diagnosis
sleep disturbance and pregnancy
airbag activation and pregnancy outcome
1st. trimester paracetamol and birth defects
bacterial vaginosis organisms and preterm labour
magnesium sulphate and obstetric practice
depth of excision at LEEP cone biopsy and risk of premature delivery
psychological response to miscarriage of pregnancies conceived with ART in infertile women
OHSS and livebirth rates after IVF in women with PCO and PCOS
neural pathway activation in physical pain and grief after TOP for fetal abnormality
maternal low-dose aspirin safe for pre-term babies
low T4 linked to increased risk of abnormal fetal position and assisted delivery
progesterone protective of brain cells after head injury?
singletons born after PGD / PGS not at increased risk for abnormality or death
trunk bending at 34 weeks at work increases PTB risk
maternal mortality & morbidity in Jehovah's witnesses
swine flu: drug therapy safety in pregnancy and lactation
rosiglitazone v. ovarian drilling in clomiphene resistant PCOS
BRCA1 mutations & ovarian insufficiency
significant absorption of oestradiol occurs with local vaginal use
stellate ganglion block & hot flushes in breast cancer patients
cystic fibrosis carrier screening linked to reduced CF incidence in neonates
does tamoxifen improve survival for lung cancer patients
COC helpful after conservative surgery for endometriosis
MRI detects most cases of placenta accreta
birth defects more common with ART
bisphosphonates may reduce breast cancer risk
stem cell transplantation offers hope in adults with severe sickle cell disease
neonatal screening for severe T-cell lymphopenia: will this become routine?
"back to sleep" figures in USA did not improve from 2003 - 2007
low early pregnancy folate levels may restrict fetal brain development
neonatal seizures are independent predictors of poor neurodevelopment
levonorgestrel IUS and endometrial protection for women on tamoxifen
propiverine effective for urgency symptoms
cervical cerclage reduces perinatal mortality for some women at high risk of premature delivery
urodynamic studies useful before prolapse surgery
aspirin and heparin of no benefit in unexplained recurrent miscarriage
dagibatran as good as warfarin in acute VTE
conservative management of placenta previa and accreta
emergency hysterectomy in obstetrics: trends and risk factors
consecutive levonorgestrel IUS use effective and not linked to significant bleeding
factors influencing survival of extremely premature babies
pre-natal air pollution linked to reduced childhood IQ
FDA updates warning on fetal risks of antiepileptic drugs
perinatal mortality higher in type II diabetes than type I
CT patients getting unnecessary exposure to radiation in the USA
mortality reduced by radical surgery cf radiotherapy for early cervical cancer: tumour < 6 cm.
prolonged 1st. stage after IOL increases risk of Cs and maternal and neonatal complications
longer duration of lactation reduces metabolic syndrome risk, particularly for women with GDM
raloxifene improves verbal memory in aged women
MRI effective in diagnosing placenta accreta
HPV vaccine effective at 6 years
laparoscopy appears comparable to laparotomy for surgical management / staging of endometrial cancer
oestrogen + progestogen HRT and risk of endometrial cancer
cancer mortality declines in Europe
prevalence of Downs syndrome rose in USA from 1979 to 2003
impaired glucose tolerance in pregnancy increases risk of metabolic syndrome
hypospadias risk linked to maternal exposure to insect repellents
new WHO guidelines for HIV and pregnancy
new WHO guidelines for HIV and infant-feeding
early TOP works in primary care in the USA
HPV screening for cervical cancer may be cost-effective
LMWH an alternative to warfarin for pregnancy + mechanical heart valves, but not perfect
high LH and low FSH levels linked to success in IVF
embryonic chromosome instability: an explanation for the low success rate of PGS?
deslenafaxine effective for hot flushes
high triglycerides linked to increased risk of PET and GDM
IMS consensus statement: "Aging, menopause, cardio-vascular disease and HRT"
Pfizer hit for $103 million in two HRT / breast cancer cases
does pregnancy slow long-term progression of MS?
ICNARC: admissions to intensive care: worth reading the introduction on pages 3 & 4.
AAGPI guideline on cell salvage in obstetrics
rivaroxaban: new oral anti-Xa anticoagulant
rivaroxaban, pregnancy & lactation
CT limitations in diagnosing PE
ellaOne: newly licensed selective progesterone receptor modulator (SPRM) for emergency contraception
enoxaparin better than warfarin in pregnant women with mechanical heart valves
do some routine labour drugs adversely affect breast-feeding rates?
AMH best predicts excessive and inadequate response to gonadotrophin therapy
metformin fails to reduce miscarriage risk in PCOS
evidence in favour of HRT for younger women
nicotine replacement appears effective and safe in pregnancy
nicotine replacement and pregnancy
prolonged 2nd. stage worse for mothers than babies
prolonged 2nd. stage gives OR of 3.35 for PPH - be prepared
puerperal haemostatic changes "HIP" study
unrepaired ASDs linked to increased PET rate and adverse neonatal outcomes
postnatal vertical transmission of HIV, breast-feeding and HAART
cost-effectiveness of BRCA screening in ovarian cancer patients
pregnancy outcomes in women with MS
pre-eclampsia & subsequent hypothyroidism
levonorgestrel IUS effective for menorrhagia & reducing fibroid size in women with fibroids
Listeria risk may be higher than previously thought
FDA licenses tranexamic acid for menorrhagia, but warns re increased VTE risk, especially with OC
doctors willing to detail their errors
maternal smoking has multiple neurodevelopmental hazards for the offspring
maternal anxiety linked to shorter pregnancy duration and smaller babes
ACOG Committee Opinion No 444: vaginal hysterectomy best method for benign conditions
preconception folic acid supplementation for at least 1 year reduces premature birth by 70%
has vaginal danazol a place in the treatment of menorrhagia?
anti-phospholipid antibodies & risk of MI & stroke: RATIO study
WHO report on contraception in women with VTE & anticoagulant therapy
are antibiotics of benefit in pre-labour elective Caesarean section?
simvastatin beats metformin in improving lipid profile in PCOS
abnormal maternal thyroid function and brain development in their children
osteoporosis linked to increased thrombo-embolism risk
bisphosphonates, raloxifene and VTE
PLD effective & safe in recurrent ovarian cancer
beta-hCG on day 14 useful predictor of miscarriage risk after single blastocyst transfer
contraception after hormone-sensitive cancer
hysterectomy v. Mirena for abdominal & back pain in women with menorrhagia
scrutiny of electronic medical records may enable early detection of domestic violence
metformin may be better than insulin for GDM
HPV vaccine may reduce progression risk in VIN
cooling neonates protects against hypoxic brain damage
microscopic evidence of necrosis may herald unexpectedly bad prognosis in endometrial cancer
infant mortality in USA higher than most of Europe, but mainly due to high % of premature births
education & support promote initiation & continuance of breast-feeding in premature babes
1st. trimester antibiotic use and birth defects
serial membrane-sweeping unhelpful in planned VBAC
medical TOP has 4 times more complications in the early weeks than surgical
BRCA1 linked to reduced ovarian reserve and subfertility
FDA approves Gardasil for prevention of genital warts in males
chlorhexidine vaginal and neonatal body wipes do not prevent vertical transmission of infection
obesity and failure rates for regional anaesthesia for Caesarean section
liquid-based cervical cytology no better than old fashioned smears
harmful consequences of treatment in RCTs may be under-reported even in august journals
US children may be getting sub-optimal vitamin D
Down's syndrome: antenatal diagnoses and live births 1989 - 200 8. National DS Cytogenic Register
parvovirus a rare cause of fetal death
soy supplements reduce rate of whole body bone loss, but not loss at key fracture sites
monthly, one-day courses of itraconazole effective in recurrent thrush
breast tenderness on starting HRT linked to increased breast cancer risk
postmenopausal exercise reduces breast cancer risk
maternal smoking & alcohol use in pregnancy linked to psychotic symptoms in adolescent offspring
SERMS & tibolone reduce breast cancer risk but increase other risks
restless genital syndrome: possible explanation
mifepristone shrinks fibroids and reduces associated blood loss
non-invasive retrieval of trophoblastic cells from cervical canal
maternal and fetal complications greatly increased in women > 40 with MP after ovum donation
hairdressers at increased risk of POF
HRT use increases the risk of ovarian cancer
folate antagonists significantly increase rates of fetal abnormality, especially NTD and CVS defects
placental site tumour prognosis worsens with late presentation
complications increase with inadequate sleep, not long working hours
SIDS linked to co-sleeping and parental alcohol and drug use
incidence of retinopathy of the prematurity linked to the degree of prematurity
method of managing early miscarriage has no effect on future fertility (MIST) trial
longer treatment of severe PMS with sertraline may be better
ART twins at increased risk of prematurity, LBW and perinatal death
breast feeding may reduce breast cancer risk in women with high-risk family histories
survival to 12 months of extremely premature babies in Sweden, 2004 - 2007
fresh and frozen embryos give similar outcomes for the fetus & neonate
bovine lactoferrin reduces infection rates in premature babies
SSRIs linked to prematurity, reduced Apgar scores and increased NIC unit admission
no improvement in survival rates of extremely premature babies in a decade
pregnancy outcomes good for women who have survived childhood cancer
obesity & congenital abnormality
occupation and poor semen quality
contraceptive patch highly effective but ? slightly less so than COC
regular exercise in pregnancy reduces risk of excessive birth weight
anaesthesia for C. section not linked to incidence of learning disability
short-term, sub-cutaneous heparin produces skin lesions in 7.5% of recipients
should all neonates have bilirubin screening?
RCOG comment on BJOG paper on TOP & pregnancy outcome
antenatal exposure to PCE increases birth defect rate by up to 50%, especially NTD and clefts
OC and smoking hugely increase risk of stroke and MI in women with anti-phospholipid syndrome
operative delivery increases risk of intervention in subsequent deliveries
high fasting blood sugar levels in 1st. trimester predict adverse outcomes, including GDM
anti-epilepsy drugs cause adverse pregnancy outcomes, not epilepsy itself
SSRIs linked to congenital heart septal defects
DMPA linked to increased # risk
single treatment of periodontal disease in pregnancy did not affect pregnancy outcomes
Bilateral oophorectomy linked to doubling of lung cancer risk.
Two papers confirm the efficacy of vaginal oestrogen in relief of local menopausal symptoms.
Dental care does not impact on risk of premature labour.
Don't be silly - prescribe Psyllium, not bran for IBS.
Dabigatran (PradaxaŠ) - an exciting new oral anticoagulant.
Can the administration of MgSO4 to mothers reduce cerebral palsy in premature babies?
Low birth weight linked to reduced bone density in adulthood.
Number of ovulatory cycles and age at menarche may influence survival with ovarian cancer.
FDA approves "Adiana"; a new, permanent, tubal contraceptive.
Single embryo transfer more effective and cheaper than double embryo transfer.
Proteinuria is a moderate predictor of SB in PET, but not of other maternal and fetal outcomes.
Sensational new outpatient test for endometriosis.
Sexual abuse linked to somatic disorder complaints throughout life.
Placental corticotropin-releasing hormone as a possible trigger for labour.
Gestational diabetes increases lifetime risk of type II diabetes seven-fold.
HPV vaccine has similar risks of adverse incidents compared to other vaccines, data from USA.
HPV vaccine risks: data from the UK: (MHRA).
Only ~ 70% of girls are accepting HPV vaccination.
Should we advocate HPV vaccine or not?
Elective induction at 41 weeks may reduce C. section rates and meconium staining.
Important recent stuff on contraception:
Oral contraception & VTE risk: BMJ editorial.
Not all women are on the safest Pill: outcomes of the MEGA study.
Hormonal contraception & VTE risk.
Contraception: good BMJ update / overview.
Air travel triples VTE risk and the risk increases by 18% for each additional 2 hours in the air.
Hormone contraception (Depot or Pill) accelerates progression of HIV disease.
ART twins at increased risk of IUGR, premature birth and perinatal death.
Scottish perinatal mortality due to intrapartum hypoxia declined by 40% from 1988 to 2007.
Mediterranean diet and exercise help prevent brain decline with age.
Denosumab: new monoclonal antibody reduces osteoclast activity and is effective in osteoporosis.
The online BMJ of 6th. August 2009 has articles on cervical screening and treatment:
effectiveness of screening for different age groups,
risk of cancer or pre-cancer developing over 3 years in women with persistent HPV,
comparison of the effectiveness of cytological follow-up and immediate colposcopy,
"see and treat" versus selective recall and treatment,
cost-effectiveness of the management options for low-grade cervical smear abnormalities,
editorial on the management of low-grade and borderline cervical abnormalities.
Early surgical menopause doubles the risk of ling cancer.
Psychological distress plus poverty increase teenage pregnancy rates in US study
H1N1 flu particularly severe in pregnant women: Lancet article - American data from CDC.
Latest WHI analysis does not support "early window of opportunity" theory for HRT.
Low SHBG levels linked to increased risk of type II diabetes in women and men.
Induce labour at 37/52 in mild PET and PIH to reduce maternal morbidity. The HYPITAT trial.
Domestic violence: screening may not always benefit those affected.
Prolonged 2nd. stage: the longer it gets, the greater the maternal and fetal risk.
Home delivery safe in low-risk women.
Wyeth used professional ghost-writers to promote HRT in supposedly objective academic papers.
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